Of interest, the mechanisms of action of these two classes of drugs are different and potentially complementary, supporting the combined use of GLP-1RAs and SGLT2i in people with type 2 diabetes [84,85,86,87,88,89]
Just a few prototypes ever reached clinical trials including a liposome-containing insulin targeted to liver cells, a silica-based particle with insulin, and a calcium phosphate-based system
31871776, 31972101, and 31771956), Natural Science Foundation of Shanghai (Grant No
The detailed study selection process is illustrated in the PRISMA flow diagram ( Supplementary Figure S1 )
Public Health 10 , 797794 (2022)
Limit alcohol intake and avoid smoking, as both rapidly deplete glutathione reserves and increase oxidative stress