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A recent meta-analysis of randomized controlled trials (RCTs), including AMPLITUDE-O, examining six GLP-1 receptor agonists (lixisenatide, liraglutide, subcutaneous semaglutide, exenatide, dulaglutide, and efpeglenatide) reported a 21% reduction in a composite kidney outcome (macroalbuminuria, doubling of serum creatinine or 40% eGFR decline, RRT, or death from kidney disease), corresponding to a number needed to treat of 47 [73]
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In the circulation and in the liver and kidneys, GIP(1-42) is inactivated by the enzyme dipeptidyl peptidase 4 (DPP-4) through cleavage of the two N-terminal amino acids ( Figure 1 )
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