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Importantly, significant effects are ascribed to both medications in terms of modification of body composition involving body fat mass (26, 27), body water content (28), skeletal mass (29), and bone mineral density (30, 31), as well as the impact on the function of different organs such as the brain (32), heart (32, 33) and pancreas ( Emerging data indicate that the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis may play a role in either mediating the metabolic and neuroendocrine effect of these drugs or responding to the profound body modifications fostered by GLP-1RAs and SGLT-2is

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