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Side effects typically peak around weeks 6-8, then improve significantly by week 12

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Profound Liver Fat Reduction: Phase 2 data showed retatrutide reducing liver fat by more than 80% at therapeutic doses, with over 80% of patients normalizing liver fat to below 5%

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Metabolic Boost: By activating the glucagon receptor, it increases resting energy expenditure, helping you burn more fat even while at rest