While chloride ligands are typically quickly exchanged under physiological conditions, bromo and in particular iodo ligands are relatively inert to hydrolysis 30,31
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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Liang J., Jahraus B., Balta E., Ziegler J.D., Hbner K., Blank N., Niesler B., Wabnitz G.H., Samstag Y
In addition, while the animal models used in preclinical studies are designed to be representative of disease states in humans, these preclinical models may not be able to accurately predict the way a product candidate will affect patients in clinical trials
This is especially important for people at risk for multiple deficiencies, including those with GI conditions, a history of gastric bypass surgery, impaired kidney function, older adults, and people taking PPIs