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Yu G, Zhang W, Ly C, Zhang H, Rice WG, and Andreeff M

The HbA1c progression and treatment intensification approach used in the present study has been used in several previously published cost-effectiveness analyses [14, 15, 30]

Even if a small fraction of an oral dose enters the systemic circulation, it is cleared long before the next dose is administered

They also have important roles in ion homeostasis, several metabolic pathways, apoptosis and programed cell death, and ROS production and consumption [13]

However, it might also have more gastrointestinal side effects and a slightly higher risk of pancreatitis