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The carnitine bound OCTN2-occluded structure defines the substrate and sodium ion binding sites In the presence of 10 mM l-carnitine the structure of OCTN2 was determined in the fully occluded, carnitine- and Na + -bound conformation (Fig

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To evaluate the effects of tirzepatide, many studies have been conducted in high-fat diet-fed, obese, insulin-resistant mice (23)