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for example, miR-135b-3p directly downregulates GPX4 and exacerbates myocardial ischemiareperfusion injury [132], whereas miR-30d and miR-190a-5p confer protection by targeting pro-ferroptotic enzymes or upregulating ferritin heavy chain [135, 136]

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An increased metabolism implies that one burns more calories at rest and hence creates a caloric deficit that is required to burn fat

Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice

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The findings open the door to a possible dual-purpose role for these drugs in treating both systemic inflammation and cardiovascular comorbidity in RA