developed a novel DON prodrug, HDON, which can selectively activate nitroreductase in hypoxic tumor environments without affecting oxygen-rich normal tissues, showing significant tumor inhibition in the H22 mouse liver cancer model (Zheng et al., 2024)
doi: 10.1111/jdi.12493 [DOI] [PMC free article] [PubMed] [Google Scholar] 27.Phillips TJ, Cherry CL, Cox S, Marshall SJ, Rice AS
This suggests that FM patients may have altered sensory processing and perception, which could contribute to FM-related pain and sensitivity
Armstrong DG, Boulton AJM, Bus SA
Assuming a 50% price erosion post-generic entry and 50% market share capture by generics, the addressable opportunity could be around USD 500 million
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