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DPP4 cleavage of the physiologically active BNP (132) to BNP (332) effectively lowers plasma cGMP levels, reduces diuresis and natriuresis, and inhibits vasodilatation (83, 202)

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These characteristics demand exceptional analytical control, especially during development, scale-up and regulatory submission

[DOI] [Google Scholar] Vernoux T, Wilson RC, Seeley KA, Reichheld JP, Muroy S, Brown S, Maughan SC, Cobbett CS, Van Montagu M, Inze D

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