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REDEFINE and SURMOUNT enrolled different cohorts (including with-diabetes vs without-diabetes arms), and diabetes status alone shifts expected weight loss

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JMJD3 acts as a histone demethylase that specifically targets histone H3 on lysine 27 (H3K27) [56]

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For example, prescribing data for one oral GLP-1 tablet reported that among patients who had gastrointestinal side effects, 60% were mild, 36% were moderate and 4% were severe