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Long-term use of opioids can lead to constipation, dependence, nausea, indigestion, irregular heartbeats, and opioid-induced hormonal imbalance resulting in menstrual irregularities, impotence, enlarged breast in males, decreased energy, and libido

Its use should be directed by a qualified clinician as part of a comprehensive plan

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The specific GST inhibitors, S-hexylglutathione and ellagic acid (Sigma-Aldrich ) were dissolved in 100% DMSO to prepare the stock solution

Some studies indicate that NAC supplementation may help alleviate symptoms of mood disorders, although more research is needed in this area