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GHRP-6 has the strongest appetite signal in the GHRP class via direct ghrelin-mimetic activity

Combining them might increase the likelihood of digestive discomfort during the first few weeks as your body adjusts

Most women notice something within the first week, even at the starter dose, though what they notice tends to surprise them

Eur.J.Gen.Med 2009;6(2):7-15

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It acts quickly to provide rapid intervention during acute oxidative stress (e.g., post-exercise or late at night)