retatrutide phase 2 trial obesity nejm 2023 Retatrutide: 3 Results (Up to 28.7% Weight Loss), Mechanism, Trials & 2026 Updates Retatrutide Research Guide: What the

For a full overview of what retatrutide's cardiovascular data shows, see our cardiovascular outcomes guide

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At week 26, LDL-C was reduced by 19.0% (-36.0% to -1.9%, p=.029) in the tirzepatide 15 mg group compared to placebo while it was reduced by 17.8% (-33.7% to -2.0%, p= 0.028) in the dulaglutide 1.5 mg group compared to placebo though differences between the 2 medications were not seen [60]

Resolution of steatohepatitis and fibrosis reduction occurred in 32.7% of semaglutide-treated patients versus 16.1% in the placebo group (estimated difference 16.5 percentage points, 95% CI 10.222.8)