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However, the structure of some AMPs has been solved which may allow a synthesis of their analogs lacking cytotoxicity

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Therefore, they are nowadays recommended as first line therapy in patients with T2DM and atherosclerotic cardiovascular disease to reduce events, regardless of baseline or target HbA1c and concomitant glucose-lowering medication according to the 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes [31]

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Potential Side Effects and Digestive Changes The most common adverse effects of Wegovy involve the gastrointestinal system, with nausea, diarrhoea, vomiting, constipation, and abdominal pain reported in clinical trials, as detailed in the MHRA-approved SmPC