In other experiments, acute stress also caused rapid downregulation of preproglucagon gene expression in the NTS neurons in rat brains [82]
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Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimers disease by suppressing NLRP2 activation in astrocytes
While we did not conduct mechanistic pharmacological studies, we speculated and hypothesized, drawing on evidence from pharmacological research, that the pharmacological action of DPP4-i and their inability to cross the bloodbrain barrier offer a plausible explanation for differences in the risk of developing major and mild CI when compared to GLP-1a [6, 31, 32]
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, Genetic effects on gene expression across human tissues, Nature, vol