With a half-life of approximately five days, you can calculate clearance using the standard pharmacokinetic model
the quiet will come as the dose increases
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)736 amide in type 2 (noninsulin-dependent) diabetic patients
Rivera FB, Lumbang GNO, Gaid DRM, Cruz LLA, Magalong JV, Bantayan NRB, Lara-Breitinger KM, Gulati M, Bakris G
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Most menstrual changes do not require treatment discontinuation but may benefit from dosing adjustment or slower titration