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revealed that AS-IV inhibits the Ca2 + /CaMKII/CaN pathway by attenuating calcium-sensing receptor sensitivity, reducing Ca 2+ release from the sarcoplasmic reticulum, and decreasing intracellular Ca 2+ to prevent calcium overload (Lu et al., 2018)

So GHRH(1-29) is essentially the minimal sequence needed for the receptor agonism mechanism

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