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Oxidative stress mainly damages cartilage homeostasis through excessive accumulation of reactive oxygen species (ROS)

(3) IIRI + MET group: treated with metformin (1 mg/mL in drinking water) for one week prior to IIRI

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6 , CD001190 (2018)

It is plausible that betaine supplementation promotes athletic performance by maintaining cellular hydration and reducing homocysteine levels, thereby encouraging healthy cardiovascular function and blood flow [16]