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-thal, a kind of hemolytic anemia, is closely related to abnormal embryonic erythropoiesis, thus, its pathogenesis may be probably highly linked to ferroptosis

It is carcinogenic (cancer causing), immune suppressive, and can cause liver disease

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The surveillance of abnormal nucleic acids from invading pathogens or damaged cells is conducted by PRRs including RIG-I, melanoma differentiation-associated gene 5 (MDA5), cyclic GMP-AMP synthase (cGAS), and absent in melanoma 2 (AIM2)

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10.1038/nature09146