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Brain opioid receptor measurements by positron emission tomography in normal cycling women: relationship to luteinizing hormone pulsatility and gonadal steroid hormones 1

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In clinical trials, tirzepatide demonstrated significant reductions in hemoglobin A1c levels (up to 2.5% reduction in SURPASS diabetes trials) and body weight (up to 20% reduction in SURMOUNT obesity trials) compared to placebo and other medications