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Safety, efficacy, and feasibility of intranasal insulin for the treatment of mild cognitive impairment and Alzheimer disease Dementia: A randomized clinical trial

However, it is especially remarkable that within the SUMMIT trial, among patients with HFpEF, the dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide agonist, tirzepatide, significantly reduces the combined risk of cardiovascular death or the exacerbation of HF

N.HolmgrenA.ContelM.et al (2016)

Further research investigating time-course changes in citrulline concentration following CM supplementation is required to determine the optimal strategy, although the best recommendation at the moment would be 1 h prior to exercise

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These medications work by improving how the body manages blood sugar, helping to reduce insulin spikes and support better glucose metabolism overall