weight regain semaglutide and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension Caution.... A recent BMJ systematic

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and NAFLD, also referred to as metabolic dysfunction-associated steatotic liver disease (MASLD), the ADA recommends considering a GLP-1 receptor agonist or a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist as part of the treatment plan

125,130 In 2022, tirzepatide was approved by the FDA for the treatment of T2DM in the United States

It is well appreciated that accumulation of ectopic fat, especially in the liver, can lead to an insulin-resistant state predominantly mediated by negative-feedback interference on insulin signal transduction pathways 79,80

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50.3%), followed by anxiety (n = 144