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A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease

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Gastrointestinal issues such as nausea, vomiting, diarrhoea, and constipation is common among users

Increases in blood vessel constriction by COX-2 inhibition can also lead to the hypertension and renal failure seen in some studies of non-selective and COX-2 selective NSAIDs (Conaghan 2012)

Vitamin B-12 is essential for the creation of DNA and the metabolism of cells, and deficiencies in these can lead to anemia, fatigue, muscle weakness, digestive issues, nerve damage, and mood swings

Environmental-induced oxidative stress in neurodegenerative disorders and aging