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These are not hypothetical risks

Wasser, C

Animal studies suggest that high concentrations of 1,25(OH)2D are necessary to generate Tregs when supplemented, but this can lead to adverse side effects such as hypercalcemia

NOX2-ROS, on the other hand, suppresses STAT5 phosphorylation and GATA-3 expression, relieving the Th2 bias against Th1 and indirectly promoting Th1 differentiation

Under conditions of insulin resistance, -cells are compelled to maintain glycemic control through compensatory hypersecretion of insulin