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Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing

Tell your brain youre full, stimulate insulin release when blood sugar rises, slow gastric emptying, suppress glucagon secretion

Genes exhibiting false discovery rate (FDR)-adjusted P 2 were considered significant and subjected to further analysis

VH: Project administration, Writing review & editing

Temporary adjustments in bowel movements, including mild diarrhea, constipation, or transient bloating

Predictors of relapse in alcohol use disorder: identifying individuals most vulnerable to relapse