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Furthermore, the expression of genes associated with mitochondrial biogenesis, including PGC-1, Nrf1, NRF2, and TFAM, was observed to have decreased in brain tissue samples from AD patients (Kerr et al., 2017)

In summary, the combination of sertraline and chloroquine targets different aspects of metabolic rewiring in GBM cells, i.e., nucleotide synthesis, redox homeostasis, and mitochondrial function, causing severe impairment of their proliferation and survival capabilities

Paracrine regulation of melanogenesis

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