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Inflammation and oxidative stress are two major stimuli in OA development 39

Xu Y, Huo Y, Toufektsian MC, Ramos SI, Ma Y, Tejani AD, et al

With these robust findings, CagriSema has the potential to be the first amylin and GLP-1 combination therapy that addresses blood glucose control with reductions in bodyweight for people living with type 2 diabetes." Amylin, a pancreatic hormone co-secreted with insulin in response to food intake, plays a distinct yet complementary role to GLP-1, with potential roles in appetite, glycemic control, bone metabolism, and bodyweight

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