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The release of HGF, in conjunction with c-MET, triggers subsequent processes that result in STAT3 phosphorylation, thereby facilitating the growth of functional MDSCs [81]

Furthermore, investigations have demonstrated that the combination of nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P450 reductase (POR) and nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase (CYB5R1) allows electrons from NAD(P)H to react with O2, generating H2O2

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