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Ammonia triggers exocytotic release of L-glutamate from cultured rat astrocytes

Significant reduction in all-cause mortality with Ozempic 1 For adults with T2D and CKD for a confirmatory secondary endpoint: time to first occurrence of all-cause mortality vs placebo when both were added to standard of care 1,2 All cause death 1-3 1-3 cc 2.5% ARR reported at 3 years in pre-specified supplementary analysis

Taken together, these findings justified taking Sm-TSP-2 (made in Pichia pastoris ) forward in clinical trials

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pallida ) in complex with ADP and the canonical di-peptide substrate -EC (2.5 , PDB 5OES)

These certifications require documented procedures, quality control checks, and regulatory oversight