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The mechanisms underlying the atherogenic and thrombogenic effects of TMAO include enhanced foam cell formation, reduced reverse cholesterol transport, and induction of platelet aggregation 9,10,12,15

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SAC inhibits TGF-1induced myofibroblast differentiation, downregulates AKT/NF-B signaling, and preserves thiol homeostasis

Using sterile water instead of BAC water Sterile water has no preservative, so bacteria can grow in multi-dose vials

Twelve patients with type 2 diabetes were included in this placebo-controlled, double-blinded study