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PMCID: PMC6078216

Sensorgram data were processed and analyzed using the Biacore T200 Evaluation Software (version 3.2.1) with a 1:1 Langmuir binding model to calculate apparent binding affinity (KD) values

Copper-Coordination Research Copper is a redox-active transition metal used by multiple enzymes and molecular systems

Methylfolate provides the biologically active form without requiring DHFR conversion and may therefore be preferable where reduced enzyme activity is suspected

Cagrilintide combined with semaglutide (CagriSema) is an investigational combination that pairs semaglutide with an amylin receptor agonist