The interaction is not dose-proportional receptor saturation dynamics are unpredictable and vary by individual baseline neurotransmitter levels
Yamazaki, N., Shinohara, Y., Shima, A
Plant-Based Diets and B12 Intake Many people thrive on plant-based diets, but one nutrient that requires extra attention is B12
Singleton KD, Wischmeyer PE
Studies have shown that GLP-1-based therapies can reduce both mast cell and macrophage infiltration in various organ systems, potentially explaining why patients often experience improvements across multiple symptoms simultaneously
These are separate B12-dependent pathways, and the cofactor requirements are not interchangeable. When your adenosylcobalamin status is low whether from inadequate intake, poor conversion, or impaired mitochondrial B12 transport MUT activity drops, methylmalonyl-CoA accumulates, and MMA rises