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Regulatory agencies in some regions have issued warnings that these extreme, non-therapeutic doses can put undue stress on the kidneys and liver

Palomares, K., Vigant, F., Van Handel, B., Pernet, O., Chikere, K., Hong, P., Sherman, S.P., Patterson, M., An, D.S., Lowry, W.E., Mikkola, H.K., Morizono, K., Pyle, A.D., and Lee, B., "Nipah virus envelope pseudotyped lentiviruses efficiently target ephrinB2+ stem cell populations in vitro and bypass the liver sink when administered in vivo", J Virol (2012)

& Kinugawa, K

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Update on the Japanese guidelines for the use of infliximab and etanercept in rheumatoid arthritis