For over-the-counter topical use, look for 0.5% to 2% in a vehicle that supports skin penetration, such as a low-molecular-weight carrier or liposomal formulation
Its high glycine content can also help relax the muscles and support the nervous system, which may make the overall experience of cramping less intense
[PubMed] [Google Scholar] 37.Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T
Extra caution may apply with asthma or chronic lung disease, diabetes, thyroid disease, liver impairment, circulation problems, pregnancy, or breastfeeding
It may depend on time, according to a new study discussed in the Folate section of our B Vitamin Supplements Review
Reduced network connectivity of metabolites involved in methylation and polyamine metabolism suggests altered pathway integration after dietary modification