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In therapeutic applications, examples include the increase in biological activity and improvement of metabolic stability by N-methylation 17,18 , increasing binding affinity 4,19 , half-life increase and improvement of tissue penetrating abilities by lipidation and acylation 6

Lactate production and pyruvate consumption provide additional metabolic biomarkers that reflect the balance between glycolytic and oxidative metabolism in developing embryos

Split dosing lifts the trough by providing a second dose before levels fall too far

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Moreover, the waist circumference of the L

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