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Some studies have reported that Th2 cell-related cytokines including IL-4 and IL-13 are highly expressed in the synovial fluid of early RA patients, functioning as anti-inflammatory cytokines that inhibit the differentiation of Th1 and Th17

In addition, there is a U-shaped association between selenium exposure and some diseases, such as type 2 diabetes and fractures [117]

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Available at: Accessed December 4, 2012