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doi: 10.1002/dev.22404 195

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[4,13] Any impairment in insulin transport due to receptor dysfunction, BBB damage, or insulin resistance can lead to: [14] Reduced glucose utilization Neuronal energy failure Impaired synaptic signaling Increased neuronal hyperexcitability Higher risk of seizures and cognitive decline Thus, proper transport and distribution of insulin in the brain is fundamental for maintaining neuronal homeostasis and seizure control