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doi: 10.3389/fvets.2025.1502236 Received 26 September 2024 Accepted 21 May 2025 Published 30 June 2025 Volume 12 - 2025 Edited by Maurice Pitesky, University of California, Davis, United States Reviewed by Blagica Sekovska, Saints Cyril and Methodius University of Skopje, North Macedonia Christine Pye, University of Liverpool, United Kingdom Updates Copyright 2025 Tarrant, Rai, Wright, Street and Wells

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Anyone considering this supplement should factor both of those realities into their decision: promising preclinical signal, very limited human clinical confirmation, no significant adverse effects observed in the small human studies that do exist

Research links it to signaling involved in skin remodeling, antioxidant defense, and repair processes, which is why it is used for visible aging concerns, barrier support, and scalp-focused routines

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Additionally, the method of administration can also impact the duration that steroids stay in the body