Dahl D, Onishi Y, Norwood P et al (2022) Effect of subcutaneous tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: the SURPASS-5 randomized clinical trial
It mainly includes increased concentrations of total cholesterol and/or triacylglycerol, as well as decreased concentrations of high-density lipoprotein cholesterol, which is one of the independent risk factors for cardiovascular and cerebrovascular diseases
These oxidation products enhance the catabolism of retinoic acid by inducing the activity of the cytochrome P450 enzyme
Moreover, TMAO can cross the BBB
Eur J Pharmacol 570(13):212221 Whang R, Papper S, Llach F (1988) Arginine-induced hypermagnesemia and hyperkalemia in nephrectomized rats
Subcutaneous adipose tissue transplantation in diet-induced obese mice attenuates metabolic dysregulation while removal exacerbates It