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1 Introduction Diabetes has become one of the major public health burdens in the world

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Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study

The homocysteine remethylation is catalyzed by methionine synthase, which uses N 5 -methyltetrahydrofolate (5-methylTHF) as the methyl donor and cobalamin as the cofactor (Fig