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It may be especially noted that, in the active site of enzymes, the contribution of solvation from water is usually minimal and thus the information gained by exploiting some sophisticated techniques of modern mass spectrometry may better contribute to understanding biochemical mechanisms

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A key physiological difference between the two incretin hormones, GIP and GLP-1, is therefore, that GIP is able to stimulate glucagon secretion, whereas GLP-1 suppresses glucagon secretion (18)