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Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress

But LHRH antagonists, such as Cetrorelix, are under investigation in clinical trials

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In ARPE-19 cells, we found that, compared to SG, HG significantly increased the mRNA expression of these genes 24 h after exposure (Fig