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DOI: 10.1371/journal.pone.0020592

Effectiveness of delivery routesinjectable versus oral/nasal absorption, stability of formulation

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The enhanced hepatic mitochondrial activity in the context of TKT deficiency has been shown to be the result of increased phospholipid synthesis, particularly increased synthesis of phosphatidylcholine which represents the major phospholipid in the mitochondrial membrane

In particular, one of oridonin derivate (HAO472) is currently in phase I clinical trials in China for the treatment of a type of leukemia ( 2+ concentrations, and hemolysis ( Benzethonium chloride is a synthetic quaternary ammonium salt with antimicrobial properties, widely used in liquid antiseptics, in cosmetics (National Center for Biotechnology Information), and as a preservative in vaccines (Yip et al., 2006)

The transdermal composition of claim 2 which sustains constant plasma levels of GHK-Cu or copper tripeptide in an animal from at least 48 hrs - 72 hrs after application