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In contrast, antagonists of 2 adrenergic, dopamine D2, dopamine D3, and serotonin 5-HT2A/C receptors fail to affect tesofensine's hypophagic properties, indicating the specific receptor pathways responsible for its therapeutic effects

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M., Meyer, K., & Murphy, M

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The increase in the males could be explained by a higher concentration gradient for the buprenorphine to leave the SC tissues, resulting in a higher-than-predicted C max and AUC 0-t [18]