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To generate the DNA templates for transcription, plasmids were amplified in DH5 bacterial strain, purified and linearised 3 to the cloned sequence using the SpeI restriction site

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In MOMPOD, there was again no difference in primary composite neonatal outcomes, maternal weight gain or insulin use compared with placebo

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Its unique pharmacodynamic profile as a partial -opioid receptor agonist and -opioid receptor antagonist provides both efficacy and an improved safety margin relative to full opioid agonists