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Glutathione in a reduced state can be found naturally within cells.

Although evidence of efficacy is lacking, the manufacturers claim improvement of melasma, hyperpigmentation and skin ageing.[19 Biological activity : The glutathione redox cycle : Glutathione exists in two interconvertible forms, reduced glutathione (GSH) and oxidized glutathione (GSSG)

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It was initially developed as a scavenger of OH and other ROS, but may exert effects through other mechanisms in vivo [436]