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Although selective serotonin reuptake inhibitors and cognitive behavioral therapy typically form the first line of treatment for people who have depression, several non-pharmacological adjunct therapies have demonstrated effectiveness in modulating depressive symptoms, including exercise, dietary modification (especially interventions that capitalize on circadian rhythms), meditation, sauna use, and light therapy, among others

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This represents a gap in the evidence base that researchers should acknowledge when making decisions about protocol adoption

43 Thus, the characteristics of this series of patient are consistent with the notion that the systemic abnormalities seen in this subgroup of ASD patients may arise from environmental triggers 7 in genetically sensitive subpopulations