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10.1016/j.fct.2020.111282 44 ReitmanS.FrankelS

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Adverse reaction 1) If overdose, the following adverse reactions may occur: Headache, asthenia, fatigue, muscle pain, Loss of appetite, weight loss, growth disorder, nausea, vomiting, constipation, diarrhea, polydipsia, polyuria, dehydration, high blood pressure, calcium oxalate stones, tissue calcification, kidney disease, vascular disease, and kidney failure

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After GPx consumes part of the initial H 2 O 2 substrate, the remaining H 2 O 2 interacts with ferrous ions (Fe 2+ ), proceeding through a classic Fenton-type redox reaction that oxidizes Fe 2+ ions to ferric ions (Fe + )

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