Insulin is highly effective at lowering blood sugar but typically causes weight gain (4-8 kg in the first year) and carries significant hypoglycemia risk
[1] Note the comparator carefully: it was liraglutide, not tirzepatide
Heartburn is a side effect of delayed gastric emptying, which is one mechanism through which tirzepatide works
Nonetheless, contrasting findings of non-significant cardiometabolic risks among adolescent SAM survivors have been documented, despite shorter height attainment during catch-up growth [225]
This can lead to a feeling of fullness and, as a result, reduced food intake
Figure 4 Due to the influence of renal clearance and dipeptidyl peptidase-4 (DPP-4), GLP-1 has a short natural half-life in the human body, about 12 min (113)